Pemetrexed disodium (Alimta)

Name: Pemetrexed disodium (Alimta)
SKU: A10707
Price: 140 CNY
Rating: 5 (1 reviews)

目录号: A10707

DHFR 抑制剂

1 篇发表文献

Pemetrexed 二钠在化学上与叶酸相似，属于被称为叶酸拮抗剂的化疗药物类别。它的作用机制是抑制嘌呤和嘧啶合成中使用的三种酶——胸苷酸合成酶（TS）、二氢叶酸还原酶（DHFR）和甘氨酰核苷酸甲酰基转移酶。

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Grouped product items
规格	价格	库存
10mg	¥140.00	现货
25mg	¥245.00	现货
50mg	¥350.00	现货
100mg	¥455.00	现货
200mg	¥630.00	现货
500mg	¥1,015.00	现货
1g	¥1,505.00	现货
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Data Sheet

SDS

Other Forms of Pemetrexed disodium (Alimta)

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Pemetrexed disodium (Alimta)发表的1篇文献

Adi Jacob Berger, .et al. , Nat Cancer, 2021, 2, 1055-1070 PMID: 35121883

生物活性

Discription

Pemetrexed disodium is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis?€?thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10707
分子式	C20H19N5Na2O6
分子量	471.4
CAS号	150399-23-8
SMILES	C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
其他名称	LY-231514
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Insoluble
	Water	87 mg/mL (184.56 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.21 mL	106.07 mL	212.13 mL
0.5 mM	4.24 mL	21.21 mL	42.43 mL
1 mM	2.12 mL	10.61 mL	21.21 mL
5 mM	0.42 mL	2.12 mL	4.24 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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