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Pexidartinib (PLX3397)


CSF1/Kit/FLT3 抑制剂

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产品目录号: A15520


产品名 目录号 价格 数量
Pexidartinib 10mg A15520-10
¥ 750.00
Pexidartinib 25mg A15520-25
¥ 1,500.00
Pexidartinib 50mg A15520-50
¥ 2,400.00



Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.

Pexidartinib (PLX3397)




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Chemical Information

目录号 A15520
Mechanism of action Inhibitor
分子量 417.81
化学分子式 C20H15ClF3N5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1029044-16-3
Synonyms PLX-3397, PLX 3397
SMILES code FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F
化学名称 N-[5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine


Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
Kit CSF-1R Flt3
10 nM20 nM160 nM


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.93 mL 119.67 mL 239.34mL
0.5 mM 4.79 mL 23.93 mL 47.87 mL
1 mM 2.39 mL 11.97 mL 23.93 mL
5 mM 0.48 mL 2.39 mL 4.79 mL

*The above data is based on the productmolecular weight 417.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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