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Pexmetinib (ARRY-614)是通过双重抑制p38促分裂原活化蛋白激酶（MAPK）和Tie2/Tek受体酪氨酸激酶，其在HEK-293细胞中的IC50分别为4 nM/18 nM。Pexmetinib是一种有效的细胞因子合成抑制剂。
靶点信息
| p38 MAPK | Tie-2 | |||
| In vitro | DMSO | 96 mg/mL (172.46 mM) | |
| Water | Insoluble | ||
| Ethanol | 96 mg/mL (172.46 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.97 mL | 89.83 mL | 179.65 mL |
| 0.5 mM | 3.59 mL | 17.97 mL | 35.93 mL |
| 1 mM | 1.8 mL | 8.98 mL | 17.97 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.59 mL |
*The above data is based on the productmolecular weight 556.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10895 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 556.63 |
| Formula | C31H33FN6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 945614-12-0 |
| Synonyms | ARRY614, ARRY 614 |
| SMILES | O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5 |
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