Pexmetinib (ARRY-614)

Name: Pexmetinib (ARRY-614)
SKU: A10895
Price: 315 CNY
Rating: 5 (288 reviews)

目录号: A10895

p38 MAPK 抑制剂

Pexmetinib 是一种强效的细胞因子合成抑制剂，通过双重抑制 p38 丝裂原活化蛋白激酶（MAPK） 和 Tie2/Tek 受体酪氨酸激酶 来发挥作用。

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Grouped product items
规格	价格	库存
2mg	¥315.00	现货
5mg	¥595.00	现货
10mg	¥1,050.00	现货
25mg	¥2,170.00	现货
50mg	¥3,115.00	现货
100mg	¥4,130.00	现货
*10mM 1mL in DMSO**	¥805.00	现货
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Data Sheet

SDS

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生物活性

Discription

Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.

Targets

Target	Value

产品信息

目录号	A10895
分子式	C31H33FN6O3
分子量	556.63
CAS号	945614-12-0
SMILES	O=C(NCC1=CC(F)=CC=C1OC2=CC3=C(N(CCO)N=C3)C=C2)NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5
其他名称	ARRY614, ARRY 614
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	96 mg/mL (172.46 mM)
	Water	Insoluble
	Ethanol	96 mg/mL (172.46 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.97 mL	89.83 mL	179.65 mL
0.5 mM	3.59 mL	17.97 mL	35.93 mL
1 mM	1.8 mL	8.98 mL	17.97 mL
5 mM	0.36 mL	1.8 mL	3.59 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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