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PF-04554878 (Defactinib)

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FAK 抑制剂

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产品目录号: A11929

库存状态:中国现货中国现货 In Stock, Over Night Shipping Available

产品名 目录号 价格 数量
PF-04554878 5mg A11929-5
¥ 700.00
PF-04554878 10mg A11929-10
¥ 900.00
PF-04554878 25mg A11929-25
¥ 1,800.00
PF-04554878 2mg A11929-2
¥ 400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PF-04554878 is a novel FAK kinase inhibitor that decreases growth and induces apoptosis in pancreatic neuroendocrine tumor cells

PF-04554878 (Defactinib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PF-04554878 (Defactinib) 发表的文献 (1)
  • Shalana O'Brien, .et al. FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics, Oncotarget., 2014, Sep; 5(17): 7945每7959. PMID: 25277206

Chemical Information

目录号 A11929
Mechanism of action Inhibitor
分子量 510.49
化学分子式 C20H21F3N8O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1345713-71-4, 1073154-85-4
Synonyms PF-4554878, VS-6063
SMILES code O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1
化学名称 N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

生物活性

Description
PF-04554878 is a novel FAK kinase inhibitor that decreases growth and induces apoptosis in pancreatic neuroendocrine tumor cells

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.59 mL 97.95 mL 195.89mL
0.5 mM 3.92 mL 19.59 mL 39.18 mL
1 mM 1.96 mL 9.79 mL 19.59 mL
5 mM 0.39 mL 1.96 mL 3.92 mL

*The above data is based on the productmolecular weight 510.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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