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PF-04929113 (SNX-5422)

Hsp90 抑制剂

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产品目录号: A11074

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PF-04929113 5mg A11074-5
¥ 1,500.00
PF-04929113 10mg A11074-10
¥ 2,800.00
PF-04929113 50mg A11074-50
¥ 6,000.00
PF-04929113 100mg A11074-100
¥ 10,500.00
PF-04929113 (SNX-5422) 10mM * 1mL in DMSO A11074-10mM-D
¥ 2,150.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.

PF-04929113 (SNX-5422)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PF-04929113 (SNX-5422) 发表的文献 (1)
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107每113

Chemical Information

目录号 A11074
Mechanism of action Inhibitor
分子量 521.5
化学分子式 C25H30F3N5O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 908115-27-5
Synonyms PF04929113, SNX5422
SMILES code CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C
化学名称 (1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate

生物活性

Description
PF-04929113 (SNX-5422) is orally bioavailable heat shock protein 90 (Hsp90) inhibitor.
Targets
HER2 HSP90
37 nM41 nM(Kd)

溶解性

Solubility (25°C) * In vitro DMSO 104 mg/mL (199.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (9.58 mM)
In vivo 0.5% CMC/0.25% Tween 80 25 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.18 mL 95.88 mL 191.75mL
0.5 mM 3.84 mL 19.18 mL 38.35 mL
1 mM 1.92 mL 9.59 mL 19.18 mL
5 mM 0.38 mL 1.92 mL 3.84 mL

*The above data is based on the productmolecular weight 521.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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