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PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.98 mL | 124.88 mL | 249.76 mL |
| 0.5 mM | 5 mL | 24.98 mL | 49.95 mL |
| 1 mM | 2.5 mL | 12.49 mL | 24.98 mL |
| 5 mM | 0.5 mL | 2.5 mL | 5 mL |
*The above data is based on the productmolecular weight 400.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21246 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 400.38 |
| Formula | C14H15F3N8OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1305115-80-3 |
| SMILES | NC1=C(N=NN2C[C@H]3CN(CC4=NC=CS4)CCO3)C2=NC(C(F)(F)F)=N1 |
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