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PF-04995274

PF-04995274

Name: PF-04995274
SKU: A22497

目录号: A22497

5-HT4 receptor partial agonist

PF-04995274 Chemical Structure

CAS NO. 1331782-27-4

PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay).1 It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.

库存：现货

规格	价格	数量
1 mg	￥ 200.00
5 mg	￥ 650.00
10 mg	￥ 1,100.00
50 mg	￥ 3,800.00

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.12 mL	115.6 mL	231.2 mL
0.5 mM	4.62 mL	23.12 mL	46.24 mL
1 mM	2.31 mL	11.56 mL	23.12 mL
5 mM	0.46 mL	2.31 mL	4.62 mL

*The above data is based on the productmolecular weight 432.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A22497
M. Wt	432.52
Formula	C23H32N2O6
Solubility	DMSO
Purity	>98%
Storage	at -20°C 2 years
CAS No.	1331782-27-4
Synonyms	PF-04995274, PF 04995274, PF04995274, PF-4995274, PF 4995274, PF4995274.
SMILES	OC1(CN2CCC(COC3=NOC4=C3C(O[C@H]5COCC5)=CC=C4)CC2)CCOCC1