PF-06447475

目录号: A15504

LRRK2 抑制剂

PF-06447475

PF-06447475 Chemical Structure

CAS NO. 1527473-33-1

PF-06447475是一种高效,选择性,脑渗透性LRRK2抑制剂,对Wt LRRK2/G2019S LRRK2的IC50分别为3 nM/11 nM。

库存: 现货

规格 价格 数量
10 mg
¥ 650.00
25 mg
¥ 900.00
50 mg
¥ 1,350.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PF-06447475是一种高效,选择性,脑渗透性LRRK2抑制剂,对Wt LRRK2/G2019S LRRK2的IC50分别为3 nM/11 nM。
靶点信息
LRRK2 G2019S LRRK2
3nM11nM
In vitro DMSO 56 mg/mL (183.4 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.75 mL 163.76 mL 327.51 mL
0.5 mM 6.55 mL 32.75 mL 65.5 mL
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL

*The above data is based on the productmolecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A15504
作用机制 Inhibitor (抑制剂)
M. Wt 305.33
Formula C17H15N5O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1527473-33-1
Synonyms PF06447475, PF 06447475
SMILES C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N

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