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PF-06463922

ALK 抑制剂

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产品目录号: A14207

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PF-06463922 5mg A14207-5
¥ 600.00
PF-06463922 10mg A14207-10
¥ 900.00
PF-06463922 25mg A14207-25
¥ 1,500.00
PF-06463922 10mM * 1mL in DMSO A14207-10mM-D
¥ 660.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.

PF-06463922

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Chemical Information

目录号 A14207
Mechanism of action Inhibitor
分子量 406.41
化学分子式 C21H19FN6O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1454846-35-5
Synonyms PF 06463922, PF06463922
SMILES code C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
化学名称 (10R)-7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile

生物活性

Description
PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
Targets
Target Value
ROS1ki: <0.02nM
ROS1ki: <0.02nM
ALKki: <0.07nM
ALK(L1196M)ki: 0.07nM
LTK(TYK1)IC50: 2.7nM
FERIC50: 3.3nM
FES(FPS)IC50: 6nM
PTK2B(FAK2)IC50: 14nM
TNK2(ACK)IC50: 17nM
PTK2(FAK)IC50: 17nM
NTRK2(TRKB)IC50: 23nM
NTRK2(TRKB)ki: 23nM
NTRK1(TRKA)IC50: 24nM
NTRK3(TRKC)IC50: 46nM
FRK(PTK5)IC50: 53nM
EGFR(ErbB1)T790ML858RIC50: 245nM
IGF1RIC50: 296nM
STK22B(TSSK2)IC50: 302nM
EGFR(ErbB1)T790MIC50: 319nM
DCAMKL2(DCK2)IC50: 370nM
EPHA1IC50: 375nM
JAK2IC50: 529nM

溶解性

Solubility (25°C)* In vitro DMSO 81 mg/mL (199.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol 81 mg/mL heating (199.3 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.61 mL 123.03 mL 246.06mL
0.5 mM 4.92 mL 24.61 mL 49.21 mL
1 mM 2.46 mL 12.3 mL 24.61 mL
5 mM 0.49 mL 2.46 mL 4.92 mL

*The above data is based on the productmolecular weight 406.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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