PF-06463922

目录号: A14207

ALK 抑制剂

PF-06463922

PF-06463922 Chemical Structure

CAS NO. 1454846-35-5

PF-06463922是一种有效的双重ALK/ROS1抑制剂,对ROS1,ALK(WT)和ALK(L1196M)的Ki分别为<0.02 nM,<0.07 nM和0.7 nM。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 900.00
25 mg
¥ 1,500.00
10mM * 1mL in DMSO
¥ 660.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PF-06463922是一种有效的双重ALK/ROS1抑制剂,对ROS1,ALK(WT)和ALK(L1196M)的Ki分别为<0.02 nM,<0.07 nM和0.7 nM。
Targets
Target Value
ROS1ki: <0.02nM
ROS1ki: <0.02nM
ALKki: <0.07nM
ALK(L1196M)ki: 0.07nM
LTK(TYK1)IC50: 2.7nM
FERIC50: 3.3nM
FES(FPS)IC50: 6nM
PTK2B(FAK2)IC50: 14nM
TNK2(ACK)IC50: 17nM
PTK2(FAK)IC50: 17nM
NTRK2(TRKB)IC50: 23nM
NTRK2(TRKB)ki: 23nM
NTRK1(TRKA)IC50: 24nM
NTRK3(TRKC)IC50: 46nM
FRK(PTK5)IC50: 53nM
EGFR(ErbB1)T790ML858RIC50: 245nM
IGF1RIC50: 296nM
STK22B(TSSK2)IC50: 302nM
EGFR(ErbB1)T790MIC50: 319nM
DCAMKL2(DCK2)IC50: 370nM
EPHA1IC50: 375nM
JAK2IC50: 529nM
In vitro (25°C) DMSO Warmed: 70 mg/mL (172.23 mM)
Water Insoluble
Ethanol Warmed: 26 mg/mL
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.61 mL 123.03 mL 246.06 mL
0.5 mM 4.92 mL 24.61 mL 49.21 mL
1 mM 2.46 mL 12.3 mL 24.61 mL
5 mM 0.49 mL 2.46 mL 4.92 mL

*The above data is based on the productmolecular weight 406.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A14207
作用机制 Inhibitor (抑制剂)
M. Wt 406.41
Formula C21H19FN6O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1454846-35-5
Synonyms PF 06463922, PF06463922
SMILES C[C@@H]1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

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