PF-06821497
目录号: A21388
EZH2 抑制剂
PF-06821497(化合物23a)是一种强效、选择性且可口服的增强子泽斯特同源物2(EZH2)抑制剂,对突变型Y641N EZH2的Ki值<0.1 nM。展示出强大的肿瘤生长抑制效果。
Discription | PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0.1 nM against mutant Y641N EZH2. Exhibits robust tumor growth inhibition. |
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目录号 | A21388 |
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分子式 | C22H24Cl2N2O5 |
分子量 | 467.34 |
CAS号 | 1844849-10-0 |
SMILES | COC1=C(CN2CCC(C(Cl)=CC([C@H](OC)C3COC3)=C4Cl)=C4C2=O)C(NC(C)=C1)=O |
其他名称 | PF06821497, PF 06821497 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2