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PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0.1 nM against mutant Y641N EZH2. Exhibits robust tumor growth inhibition.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.4 mL | 106.99 mL | 213.98 mL |
| 0.5 mM | 4.28 mL | 21.4 mL | 42.8 mL |
| 1 mM | 2.14 mL | 10.7 mL | 21.4 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.28 mL |
*The above data is based on the productmolecular weight 467.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21388 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 467.34 |
| Formula | C22H24Cl2N2O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1844849-10-0 |
| Synonyms | PF06821497, PF 06821497 |
| SMILES | COC1=C(CN2CCC(C(Cl)=CC([C@H](OC)C3COC3)=C4Cl)=C4C2=O)C(NC(C)=C1)=O |
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