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PF-3758309

促销

PAK4 抑制剂

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产品目录号: A11930

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PF-3758309 5mg A11930-5
¥ 500.00
PF-3758309 10mg A11930-10
¥ 800.00
PF-3758309 25mg A11930-25
¥ 1,500.00
PF-3758309 50mg A11930-50
¥ 2,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PF-3758309 is a small-molecule p21-activated kinase inhibitor inhibiting oncogenic signaling and tumor growth.

PF-3758309

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Chemical Information

目录号 A11930
Mechanism of action Inhibitor
分子量 490.2
化学分子式 C25H30N8OS
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 898044-15-0
Synonyms PF-03758309
SMILES code CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)N[C@H](CN(C)C)C5=CC=CC=C5)SC=C2
化学名称 N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

生物活性

Description
PF-3758309 is a small-molecule p21-activated kinase inhibitor inhibiting oncogenic signaling and tumor growth.
Targets
Target Value
PAK4IC50: 1.3nM
PAK1ki: 13.7nM
PAK6ki: 17.1nM
PAK5ki: 18.1nM
PAK4ki: 18.7nM
PAK3IC50: 99nM
PAK2IC50: 190nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.4 mL 102 mL 204mL
0.5 mM 4.08 mL 20.4 mL 40.8 mL
1 mM 2.04 mL 10.2 mL 20.4 mL
5 mM 0.41 mL 2.04 mL 4.08 mL

*The above data is based on the productmolecular weight 490.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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