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PF-3845

促销

FAAH 抑制剂

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产品目录号: A11183

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PF-3845 10mg A11183-10
¥ 700.00
PF-3845 50mg A11183-50
¥ 3,000.00
PF-3845 100mg A11183-100
¥ 5,000.00
PF-3845 10mM * 1mL in DMSO A11183-10mM-D
¥ 910.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It reduces inflammatory pain via a cannabinoid receptor-dependent mechanism.

PF-3845

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Chemical Information

目录号 A11183
Mechanism of action Inhibitor
分子量 456.46
化学分子式 C24H23F3N4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1196109-52-0
Synonyms PF3845
SMILES code C1CN(CCC1CC2=CC(=CC=C2)OC3=NC=C(C=C3)C(F)(F)F)C(=O)NC4=CN=CC=C4
化学名称 N-3-Pyridinyl-4-[[3-[[5-(trifluorom ethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidine carboxamide

生物活性

Description

PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It reduces inflammatory pain via a cannabinoid receptor-dependent mechanism.

Targets
FAAH
230 nM(Ki)

溶解性

Solubility (25°C) * In vitro DMSO 91 mg/mL (199.36 mM)
Water <1 mg/mL (<1 mM)
Ethanol 91 mg/mL (199.36 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.91 mL 109.54 mL 219.08mL
0.5 mM 4.38 mL 21.91 mL 43.82 mL
1 mM 2.19 mL 10.95 mL 21.91 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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