产品详情

生物活性

PFI-4是一种有效的，选择性的且细胞可渗透的BRPF1溴结构域抑制剂（IC50 = 80 nM）。相对于包括BRPF2（BRD1），BRPF3和BRD4在内的其他溴结构域，BRPF1的选择性> 100倍。

靶点信息

BRPF1	BRPF2	BRPF3
80 nM	7.9 μM	>10μM

溶解度 *

In vitro	DMSO	Warmed: 17 mg/mL (44.68 mM)
	Water	Insoluble
	Ethanol	Warmed: 5 mg/mL (13.14 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.43 mL	262.85 mL
0.5 mM	5.26 mL	26.29 mL	52.57 mL
1 mM	2.63 mL	13.14 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

*The above data is based on the productmolecular weight 380.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13451
作用机制	Inhibitor (抑制剂)
M. Wt	380.44
Formula	C21H24N4O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	900305-37-5
Synonyms	PF4, PF 4
SMILES	[H]N(C(C1=CC=CC=C1OC)=O)C2=C(N3CCCC3)C=C(N(C)C(N4C)=O)C4=C2