PF 4708671

目录号: A11755

S6 kinase 抑制剂

PF 4708671

PF 4708671 Chemical Structure

CAS NO. 1255517-76-0

PF 4708671是p70核糖体S6激酶(S6K1)的高度特异性抑制剂,可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化,而对高度相关的RSK和MSK激酶没有影响。

库存: 现货

规格 价格 数量
10 mg
¥ 600.00
25 mg
¥ 1,200.00
50 mg
¥ 2,000.00
100 mg
¥ 3,500.00
10mM * 1mL in DMSO
¥ 820.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PF 4708671是p70核糖体S6激酶(S6K1)的高度特异性抑制剂,可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化,而对高度相关的RSK和MSK激酶没有影响。
靶点信息
p70 S6K1 (Cell-free assay)
160 nM
In vitro (25°C) DMSO 30 mg/mL (76.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL (20.49 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.61 mL 128.07 mL 256.15 mL
0.5 mM 5.12 mL 25.61 mL 51.23 mL
1 mM 2.56 mL 12.81 mL 25.61 mL
5 mM 0.51 mL 2.56 mL 5.12 mL

*The above data is based on the productmolecular weight 390.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11755
作用机制 Inhibitor (抑制剂)
M. Wt 390.4
Formula C19H21F3N6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1255517-76-0
Synonyms PF4708671, PF-4708671
SMILES CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F

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