PF 4708671

Name: PF 4708671
SKU: A11755
Price: 280 CNY
Rating: 5 (2 reviews)

目录号: A11755

S6 kinase 抑制剂

2 篇发表文献

PF 4708671 是一种高度特异性的 p70 核糖体 S6 激酶（S6K1）抑制剂，它能抑制 S6K1 对 S6 蛋白的磷酸化反应，该反应是对 IGF-1 的响应，同时对高度相关的 RSK 和 MSK 激酶没有影响。

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Grouped product items
规格	价格	库存
5mg	¥280.00	现货
10mg	¥385.00	现货
25mg	¥735.00	现货
50mg	¥1,015.00	现货
100mg	¥1,890.00	现货
*10mM 1mL in DMSO**	¥490.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用PF 4708671发表的2篇文献

Amnon Wittenstein, .et al. , PLoS Biol, 2023, Nov 9;21(11):e3002355 PMID: 37943958

Nogami A, .et al. , Transl Oncol, 2018, Nov 22;12(2):336-349 PMID: 30472492

生物活性

Discription

PF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases.

Targets

Target	Value

产品信息

目录号	A11755
分子式	C19H21F3N6
分子量	390.4
CAS号	1255517-76-0
SMILES	CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F
其他名称	PF4708671, PF-4708671
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	30 mg/mL (76.84 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (20.49 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.61 mL	128.07 mL	256.15 mL
0.5 mM	5.12 mL	25.61 mL	51.23 mL
1 mM	2.56 mL	12.81 mL	25.61 mL
5 mM	0.51 mL	2.56 mL	5.12 mL

Useful Calculator

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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