PF-4989216

Name: PF-4989216
SKU: A12889
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A12889

PI3K 抑制剂

PF-4989216 是一种强效且选择性的 PI3K 抑制剂，其 IC50 分别为 p110α 2 nM、p110β 142 nM、p110γ 65 nM、p110δ 1 nM 和 VPS34 110 nM。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥350.00	现货
10mg	¥665.00	现货
25mg	¥1,330.00	现货
50mg	¥2,380.00	现货
100mg	¥2,870.00	现货
200mg	¥4,130.00	现货
*10mM 1mL in DMSO**	¥385.00	现货
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Data Sheet

SDS

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生物活性

Discription

PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12889
分子式	C18H13FN6OS
分子量	380.4
CAS号	1276553-09-3
SMILES	C1COCCN1C2=C(C(=C(S2)C3=NC=NN3)C4=C(C=C(C=C4)C#N)F)C#N
其他名称	PF4989216, PF 4989216
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	66 mg/mL (173.49 mM)
	Water	Insoluble
	Ethanol	Warmed: 6 mg/mL (15.77 mM)
In vivo	Suspended in 0.5% methylcellulose	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.44 mL	262.88 mL
0.5 mM	5.26 mL	26.29 mL	52.58 mL
1 mM	2.63 mL	13.14 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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