PF-5274857

目录号: A12775

Smoothened Inhibitor

PF-5274857 Chemical Structure

CAS NO. 1373615-35-0

PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.

库存: 现货

规格 价格 数量
5 mg
¥ 1,600.00
10 mg
¥ 2,250.00
25 mg
¥ 4,600.00
50 mg
¥ 9,300.00
10mM * 1mL in DMSO
¥ 2,510.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.
靶点信息
Smoothened Smoothened
4.6 nM(Ki)5.8 nM
In vitro (25°C) DMSO 93 mg/mL (212.83 mM)
Water 93 mg/mL (212.83 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.89 mL 114.43 mL 228.85 mL
0.5 mM 4.58 mL 22.89 mL 45.77 mL
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL

*The above data is based on the productmolecular weight 436.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12775
MECHANISM OF ACTION Inhibitor
M. Wt 436.96
Formula C20H25ClN4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1373615-35-0
Synonyms PF5274857, PF 5274857
SMILES CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C

产品标签

产品标签

其他人对该产品使用了下列标签:

使用空格分隔标签。使用单引号(')标注词组。

Product Questions

Product Questions

No Questions
Keywords:购买 PF-5274857 | PF-5274857 供应商 | 订购 PF-5274857 | PF-5274857 价格 | PF-5274857 生产商 | 订单 PF-5274857 | PF-5274857 代理商 | 购买 1373615-35-0| 1373615-35-0 供应商 | 订购 1373615-35-0 | 1373615-35-0 价格 | 1373615-35-0 生产商 | 订单 1373615-35-0 | 1373615-35-0 代理商|buy PF-5274857 | PF-5274857 Supplier | purchase PF-5274857 | PF-5274857 cost | PF-5274857 manufacturer | order PF-5274857 | PF-5274857 distributor | buy 1373615-35-0| 1373615-35-0 Supplier | purchase 1373615-35-0 | 1373615-35-0 cost | 1373615-35-0 manufacturer | order 1373615-35-0 | 1373615-35-0 distributor
Rewards