PF-5274857

Name: PF-5274857
SKU: A12775
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A12775

Smoothened 抑制剂

PF-5274857 是一种新型的 Smo 拮抗剂，它能特异性地与 Smo 结合，其 K(i) 为 4.6 ± 1.1 nmol/L，并且能完全阻断细胞中下游基因 Gli1 的转录活性，其 IC(50) 为 2.7 ± 1.4 nmol/L。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥245.00	现货
10mg	¥455.00	现货
25mg	¥875.00	现货
50mg	¥1,470.00	现货
100mg	¥2,205.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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Data Sheet

SDS

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生物活性

Discription

PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ?? 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ?? 1.4 nmol/L in cells.

Targets

Target	Value

产品信息

目录号	A12775
分子式	C20H25ClN4O3S
分子量	436.96
CAS号	1373615-35-0
SMILES	CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C
其他名称	PF5274857, PF 5274857
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	83 mg/mL (189.95 mM)
	Water	83 mg/mL (189.95 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.89 mL	114.43 mL	228.85 mL
0.5 mM	4.58 mL	22.89 mL	45.77 mL
1 mM	2.29 mL	11.44 mL	22.89 mL
5 mM	0.46 mL	2.29 mL	4.58 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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