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PF-562271

促销

FAK 抑制剂

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产品目录号: A11192

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PF-562271 5mg A11192-5
¥ 1,200.00
PF-562271 10mg A11192-10
¥ 1,800.00
PF-562271 50mg A11192-50
¥ 4,500.00
PF-562271 100mg A11192-100
¥ 8,000.00
PF-562271 10mM * 1mL in DMSO A11192-10mM-D
¥ 1,810.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities.

PF-562271

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PF-562271 发表的文献 (1)
  • Jiping Yue, .et al. In vivo epidermal migration requires focal adhesion targeting of ACF7, Nat Commun, 2016, 7: 11692 PMID: 27216888

Chemical Information

目录号 A11192
Mechanism of action Inhibitor
分子量 507.49
化学分子式 C21H20F3N7O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 717907-75-0
Synonyms PF562271
SMILES code CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C
化学名称 N-methyl-N-(3-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)methanesulfonamide

生物活性

Description
PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities.
Targets
Target Value
FAKIC50: 1.5nM
PYK2IC50: 13nM
CDK2/CyclinEIC50: 30nM
CDK3/CyclinEIC50: 47nM
CDK1/CyclinBIC50: 58nM
CDK7/CyclinH/MAT1IC50: 97nM
FLT3IC50: 97nM
GSK-3αIC50: 101nM
CDK5/p35IC50: 120nM
GSK-3βIC50: 133nM
AuroraAIC50: 145nM
CDK2/CyclinAIC50: 227nM
YESIC50: 294nM
MAPK1IC50: 340nM
FynIC50: 377nM
LCKIC50: 408nM
IGF-1RIC50: >500nM
PKAIC50: 620nM
c-SrcIC50: 797nM
CDK4IC50: >1μM
CDK6/CyclinD2IC50: >1μM
Chk1IC50: >1μM
Chk2IC50: >1μM
EGFRIC50: >1μM
EphB2IC50: >1μM
FGFR3IC50: >1μM
AblIC50: >1μM
FmsIC50: >1μM
IKKαIC50: >1μM
IKKβIC50: >1μM
JNK1α1IC50: >1μM
MEK1IC50: >1μM
p70S6KIC50: >1μM
PKBαIC50: >1μM
PKBβIC50: >1μM
PKBγIC50: >1μM
PKCαIC50: >1μM
PKCβ2IC50: >1μM
PKCδIC50: >1μM
TrkBIC50: >2.5μM
PDGFRβIC50: >3μM

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL heating (197.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.7 mL 98.52 mL 197.05mL
0.5 mM 3.94 mL 19.7 mL 39.41 mL
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL

*The above data is based on the productmolecular weight 507.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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