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PF 573228

促销

FAK 抑制剂

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产品目录号: A11235

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PF 573228 10mg A11235-10
¥ 800.00
PF 573228 25mg A11235-25
¥ 1,500.00
PF 573228 50mg A11235-50
¥ 2,500.00
PF 573228 100mg A11235-100
¥ 4,000.00
PF 573228 10mM * 1mL in DMSO A11235-10mM-D
¥ 980.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM).

PF 573228

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PF 573228 发表的文献 (2)
  • Izumi D, .et al. CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin 汕1 clustering and invasiveness in gastric cancer, Int J Cancer, 2016, Mar 1;138(5):1207-19 PMID: 26414794
  • Aya Yokota-Nakatsuma, .et al. Beta 1-integrin ligation and TLR ligation enhance GM-CSF每induced ALDH1A2 expression in dendritic cells, but differentially regulate their anti-inflammatory properties, Sci Rep, 2016, 6: 37914 PMID: 27897208

Chemical Information

目录号 A11235
Mechanism of action Inhibitor
分子量 491.5
化学分子式 C22H20F3N5O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 869288-64-2
Synonyms PF-573228, PF573228
SMILES code CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4
化学名称 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone

生物活性

Description
PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM).
Targets
FAK (Cell-free assay)
4 nM

溶解性

Solubility (25°C) * In vitro DMSO 26 mg/mL (52.9 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.35 mL 101.73 mL 203.46mL
0.5 mM 4.07 mL 20.35 mL 40.69 mL
1 mM 2.03 mL 10.17 mL 20.35 mL
5 mM 0.41 mL 2.03 mL 4.07 mL

*The above data is based on the productmolecular weight 491.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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