PF 670462

目录号: A11781

Casein kinase inhibitor

PF 670462 Chemical Structure

CAS NO. 950912-80-8

Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

库存: 现货

规格 价格 数量
10 mg
¥ 1,100.00
25 mg
¥ 2,200.00
50 mg
¥ 4,050.00
100 mg
¥ 7,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.37 mL 121.86 mL 243.72 mL
0.5 mM 4.87 mL 24.37 mL 48.74 mL
1 mM 2.44 mL 12.19 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL

*The above data is based on the productmolecular weight 410.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11781
MECHANISM OF ACTION Inhibitor
M. Wt 410.3
Formula C19H20FN5.2HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 950912-80-8
Synonyms PF670462
SMILES C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl

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