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PF 670462

Casein kinase 抑制剂

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产品目录号: A11781

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PF 670462 10mg A11781-10
¥ 1,250.00
PF 670462 25mg A11781-25
¥ 3,000.00
PF 670462 50mg A11781-50
¥ 5,400.00
PF 670462 100mg A11781-100
¥ 9,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

PF 670462

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Chemical Information

目录号 A11781
Mechanism of action Inhibitor
分子量 410.3
化学分子式 C19H20FN5.2HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 950912-80-8
Synonyms PF670462
SMILES code C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl
化学名称 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride

生物活性

Description
Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.37 mL 121.86 mL 243.72mL
0.5 mM 4.87 mL 24.37 mL 48.74 mL
1 mM 2.44 mL 12.19 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL

*The above data is based on the productmolecular weight 410.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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