Dacomitinib (PF299804, PF299)

Name: Dacomitinib (PF299804, PF299)
SKU: A11051
Price: 175 CNY
Rating: 5 (6 reviews)

目录号: A11051

EGFR 抑制剂

6 篇发表文献

Dacomitinib (PF299804, PF299) 是一种强效的、可口服的、不可逆的酪氨酸激酶抑制剂，针对人类表皮生长因子受体（HER）1（EGFR）、HER2 和 HER4。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥455.00	现货
10mg	¥840.00	现货
25mg	¥1,225.00	现货
50mg	¥1,610.00	现货
100mg	¥2,555.00	现货
200mg	¥3,220.00	现货
500mg	¥5,320.00	现货
*10mM 1mL in DMSO**	¥455.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Dacomitinib (PF299804, PF299)发表的6篇文献

Yuji Uehara, .et al. , Lung Cancer, 2025, Apr:202:108479 PMID: 40088581

Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812

Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259

Momeny M, .et al. , Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257

Majid Momeny, .et al. , Sci Rep, 2017, 7: 4204 PMID: 28646172

Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

生物活性

Discription

Dacomitinib (PF299804, PF299) is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HER2, and HER4.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11051
分子式	C24H25ClFN5O2
分子量	469.9
CAS号	1110813-31-4
SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4
其他名称	PF-299804, Dacomitinib, PF-299
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	17 mg/mL (36.17 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80, pH 9	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.28 mL	106.41 mL	212.81 mL
0.5 mM	4.26 mL	21.28 mL	42.56 mL
1 mM	2.13 mL	10.64 mL	21.28 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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