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PHA 408

IKK-2 抑制剂

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产品目录号: A13108

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PHA 408 5mg A13108-5
¥ 1,200.00
PHA 408 10mg A13108-10
¥ 2,200.00
PHA 408 25mg A13108-25
¥ 4,500.00
PHA 408 50mg A13108-50
¥ 7,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.

PHA 408

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Chemical Information

目录号 A13108
Mechanism of action Inhibitor
分子量 560.02
化学分子式 C29H27ClFN7O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 503555-55-3
Synonyms PHA-408, PHA408
SMILES code CN1CCN(CC1)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl
化学名称 8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

生物活性

Description
PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.86 mL 89.28 mL 178.57mL
0.5 mM 3.57 mL 17.86 mL 35.71 mL
1 mM 1.79 mL 8.93 mL 17.86 mL
5 mM 0.36 mL 1.79 mL 3.57 mL

*The above data is based on the productmolecular weight 560.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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