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PHA-665752

促销

c-Met 抑制剂

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产品目录号: A10713

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PHA-665752 5mg A10713-5
¥ 500.00
PHA-665752 10mg A10713-10
¥ 800.00
PHA-665752 50mg A10713-50
¥ 3,000.00
PHA-665752 100mg A10713-100
¥ 5,600.00
PHA-665752 10mM * 1mL in DMSO A10713-10mM-D
¥ 900.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.

PHA-665752

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Chemical Information

目录号 A10713
Mechanism of action Inhibitor
分子量 641.6
化学分子式 C32H34Cl2N4O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 477575-56-7
Synonyms PHA665752
SMILES code CC1=C(NC(=C1C(=O)N2CCC[C@@H]2CN3CCCC3)C)/C=C\4/C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
化学名称 (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine

生物活性

Description
PHA665752 is a small-molecule inhibitor of c-Met/HGF/SF signaling.
Targets
Target Value
c-MetIC50: 9nM
RONIC50: 68nM
Flk1IC50: 200nM
c-AblIC50: 1.4μM
FGFR1IC50: 3μM
EGFRIC50: 3.8μM
c-SrcIC50: 6μM
IGF-1RIC50: >10μM
PDGFRIC50: >10μM
AuroraA2IC50: >10μM
PKAIC50: >10μM
PKBαIC50: >10μM
CDK2IC50: >10μM
p38αIC50: >10μM
MK2IC50: >10μM
MK3IC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 128 mg/mL (199.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.59 mL 77.93 mL 155.86mL
0.5 mM 3.12 mL 15.59 mL 31.17 mL
1 mM 1.56 mL 7.79 mL 15.59 mL
5 mM 0.31 mL 1.56 mL 3.12 mL

*The above data is based on the productmolecular weight 641.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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