PHA-680632

目录号: A10714

Aurora inhibitor

PHA-680632 Chemical Structure

CAS NO. 398493-79-3

PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,600.00
50 mg
¥ 4,500.00
100 mg
¥ 7,500.00
10mM * 1mL in DMSO
¥ 1,490.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
Targets
Target Value
AuroraAIC50: 27nM
AuroraCIC50: 120nM
AuroraBIC50: 135nM
FGFR1IC50: 390nM
PLK1IC50: 780nM
FLT3IC50: 820nM
VEGFR3IC50: 1000nM
VEGFR2IC50: 1920nM
LCKIC50: 1950nM
STLK2IC50: 5500nM
In vitro (25°C) DMSO 100 mg/mL (199.35 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 10% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.94 mL 99.68 mL 199.36 mL
0.5 mM 3.99 mL 19.94 mL 39.87 mL
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL

*The above data is based on the productmolecular weight 501.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10714
MECHANISM OF ACTION Inhibitor
M. Wt 501.6
Formula C28H35N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 398493-79-3
Synonyms PHA680632
SMILES CCC1=C(C(=CC=C1)CC)NC(=O)N2CC3=C(C2)NN=C3NC(=O)C4=CC=C(C=C4)N5CCN(CC5)C

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