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Aurora 抑制剂

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产品目录号: A10714


产品名 目录号 价格 数量
PHA-680632 5mg A10714-5
¥ 900.00
PHA-680632 10mg A10714-10
¥ 1,600.00
PHA-680632 50mg A10714-50
¥ 4,500.00
PHA-680632 100mg A10714-100
¥ 7,500.00
PHA-680632 10mM * 1mL in DMSO A10714-10mM-D
¥ 1,490.00



PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.





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Chemical Information

目录号 A10714
Mechanism of action Inhibitor
分子量 501.6
化学分子式 C28H35N7O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 398493-79-3
Synonyms PHA680632
化学名称 N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide


PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
Target Value
AuroraAIC50: 27nM
AuroraCIC50: 120nM
AuroraBIC50: 135nM
FGFR1IC50: 390nM
PLK1IC50: 780nM
FLT3IC50: 820nM
VEGFR3IC50: 1000nM
VEGFR2IC50: 1920nM
LCKIC50: 1950nM
STLK2IC50: 5500nM


Solubility (25°C) * In vitro DMSO 100 mg/mL (199.35 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 10% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.94 mL 99.68 mL 199.36mL
0.5 mM 3.99 mL 19.94 mL 39.87 mL
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL

*The above data is based on the productmolecular weight 501.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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