PHA-793887

目录号: A10716

CDK Inhibitor

PHA-793887 Chemical Structure

CAS NO. 718630-59-2

PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,500.00
50 mg
¥ 4,500.00
100 mg
¥ 7,500.00
10mM * 1mL in DMSO
¥ 1,100.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines.
Targets
Target Value
CDK5/p25IC50: 5nM
CDK2/CyclinAIC50: 8nM
CDK2/CyclinEIC50: 8nM
CDK7/CyclinHIC50: 10nM
CDK1/CyclinBIC50: 60nM
CDK4/CyclinD1IC50: 62nM
GSK-3βIC50: 79nM
CDK9/CyclinT1IC50: 138nM
In vitro (25°C) DMSO 72 mg/mL (199.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol 72 mg/mL (199.18 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.66 mL 138.31 mL 276.63 mL
0.5 mM 5.53 mL 27.66 mL 55.33 mL
1 mM 2.77 mL 13.83 mL 27.66 mL
5 mM 0.55 mL 2.77 mL 5.53 mL

*The above data is based on the productmolecular weight 361.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10716
MECHANISM OF ACTION Inhibitor
M. Wt 361.5
Formula C19H31N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 718630-59-2
Synonyms PHA793887
SMILES CC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C

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