|2.7 μM(Ki)||5.2 μM(Ki)|
|In vitro (25°C)||DMSO||82 mg/mL (200.19 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||60 mg/mL (146.48 mM)|
|In vivo||5% DMSO/95% Corn oil||5 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||24.41 mL||122.07 mL||244.14 mL|
|0.5 mM||4.88 mL||24.41 mL||48.83 mL|
|1 mM||2.44 mL||12.21 mL||24.41 mL|
|5 mM||0.49 mL||2.44 mL||4.88 mL|
*The above data is based on the productmolecular weight 409.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|MECHANISM OF ACTION||Inhibitor|
|Storage||at -20°C 3 years Powder|
Triciribine phosphate inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of A…
SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a con…
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) wi…
AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors …
ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).