PI-103

目录号: A10726

PI3K Inhibitor

PI-103 Chemical Structure

CAS NO. 371935-74-9

PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 700.00
25 mg
¥ 1,400.00
50 mg
¥ 2,200.00
10mM * 1mL in DMSO
¥ 940.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.
Targets
Target Value
p110αIC50: 2nM
p110βIC50: 3nM
p110δIC50: 3nM
p110γIC50: 15nM
DNA-PKIC50: 23nM
mTORIC50: 30nM
In vitro (25°C) DMSO 24 mg/mL (68.89 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.7 mL 143.51 mL 287.03 mL
0.5 mM 5.74 mL 28.7 mL 57.41 mL
1 mM 2.87 mL 14.35 mL 28.7 mL
5 mM 0.57 mL 2.87 mL 5.74 mL

*The above data is based on the productmolecular weight 348.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10726
MECHANISM OF ACTION Inhibitor
M. Wt 348.4
Formula C19H16N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 371935-74-9
Synonyms PI103
SMILES C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O

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