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PI-3065

促销

p110?? 抑制剂

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产品目录号: A14338

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PI-3065 5mg A14338-5
¥ 900.00
PI-3065 10mg A14338-10
¥ 1,500.00
PI-3065 25mg A14338-25
¥ 3,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM

PI-3065

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PI-3065 发表的文献 (1)
  • Pridham KJ, .et al. PIK3CB/p110汕 is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Chemical Information

目录号 A14338
Mechanism of action Inhibitor
分子量 506.64
化学分子式 C27H31FN6OS
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 955977-50-1
Synonyms PI3065, PI 3065
SMILES code C1CC1CN2CCN(CC2)CC3=CC4=C(S3)C(=NC(=N4)C5=C(C=CC6=C5C=CN6)F)N7CCOCC7
化学名称 6-(4-CyclopropylMethyl-piperazin-1-ylMethyl)-2-(5-fluoro-1H-indol-4-yl)-4-Morpholin-4-yl-thieno[3,2-d]pyriMidine

生物活性

Description
PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM
Targets
Target Value
p110δIC50: 15nM
p110βIC50: 1078nM
p110αIC50: 2299nM
mTORIC50: 9082nM
DNA-PKIC50: >10000nM
p110γIC50: 27542nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.74 mL 98.69 mL 197.38mL
0.5 mM 3.95 mL 19.74 mL 39.48 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL

*The above data is based on the productmolecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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