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PIK-75

PI3K 抑制剂

158 Customer Reviews
产品目录号: A10729

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PIK-75 10mg A10729-10
¥ 400.00
PIK-75 25mg A10729-25
¥ 700.00
PIK-75 50mg A10729-50
¥ 1,200.00
PIK-75 100mg A10729-100
¥ 1,700.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.

PIK-75

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PIK-75 发表的文献 (1)
  • Pridham KJ, .et al. PIK3CB/p110汕 is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Chemical Information

目录号 A10729
Mechanism of action Inhibitor
分子量 488.7
化学分子式 C16H14BrN5O4S.HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 372196-77-5
Synonyms PIK75
SMILES code CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C/C2=CN=C3N2C=C(C=C3)Br.Cl
化学名称 2-​methyl-​5-​nitro-​2-​[(6-​bromoimidazo[1,​2-​a]pyridin-​3-​yl)methylene]-​1-​methylhydrazide-​benzenesulfonic acid

生物活性

Description
PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 µM and 1.3 µM, respectively.
Targets
DNA-PK (Cell-free assay) p110α (Cell-free assay) p110γ (Cell-free assay) p110δ (Cell-free assay) p110β (Cell-free assay)
2 nM5.8 nM76 nM0.51 μM1.3 μM

溶解性

Solubility (25°C)* In vitro DMSO 3 mg/mL (6.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.46 mL 102.31 mL 204.62mL
0.5 mM 4.09 mL 20.46 mL 40.92 mL
1 mM 2.05 mL 10.23 mL 20.46 mL
5 mM 0.41 mL 2.05 mL 4.09 mL

*The above data is based on the productmolecular weight 488.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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