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PI3K 抑制剂

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产品目录号: A10731


产品名 目录号 价格 数量
PIK-93 5mg A10731-5
¥ 700.00
PIK-93 10mg A10731-10
¥ 1,200.00
PIK-93 25mg A10731-25
¥ 2,200.00
PIK-93 50mg A10731-50
¥ 3,800.00
PIK-93 10mM * 1mL in DMSO A10731-10mM-D
¥ 900.00



PIK 93 selectively inhibits the type III PI 4-kinase enzyme, and small interfering RNA-mediated down-regulation of the individual PI 4-kinase enzymes.





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PIK-93 发表的文献 (1)
  • Gavin Ka Yu Siu, .et al. Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase III汐 to induce mitochondrial fragmentation, Sci Rep, 2016, 6: 23464 PMID: 27010100

Chemical Information

目录号 A10731
Mechanism of action Inhibitor
分子量 389.9
化学分子式 C14H16ClN3O4S2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 593960-11-3
Synonyms PIK93
SMILES code CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO
化学名称 N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide


PIK 93 selectively inhibits the type III PI 4-kinase enzyme, and small interfering RNA-mediated down-regulation of the individual PI 4-kinase enzymes.
Target Value
p110γIC50: 16nM
PI4KIIIβIC50: 19nM
p110αIC50: 39nM
DNA-PKIC50: 64nM
p110δIC50: 120nM
C2βIC50: 140nM
hsVps34IC50: 320nM
ATMIC50: 490nM
p110βIC50: 590nM
PI4KIIIαIC50: 1.1μM
mTORC1IC50: 1.38μM
C2αIC50: 16μM
ATRIC50: 17μM
PI4KIIαIC50: >100μM
PI4P5KIαIC50: >100μM
PI4P5KIβIC50: >100μM
PI5P4KIIβIC50: >100μM


Solubility (25°C) * In vitro DMSO 78 mg/mL (200.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.65 mL 128.24 mL 256.48mL
0.5 mM 5.13 mL 25.65 mL 51.3 mL
1 mM 2.56 mL 12.82 mL 25.65 mL
5 mM 0.51 mL 2.56 mL 5.13 mL

*The above data is based on the productmolecular weight 389.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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