Piperlongumine

Name: Piperlongumine
SKU: A14124

目录号: A14124

TrxR1/CRM1 抑制剂

Piperlongumine Chemical Structure

CAS NO. 20069-09-4

Piperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。

库存：现货

规格	价格	数量
25 mg	￥ 900.00
50 mg	￥ 1,500.00
10mM * 1mL in DMSO	￥ 600.00

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产品详情

生物活性

靶点信息

reactive oxygen species (ROS)

溶解度 *

In vitro (25°C)	DMSO	Warmed: 15 mg/mL (47.26 mM)
	Water	Insoluble
	Ethanol	Warmed: 6 mg/mL (18.9 mM)
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.52 mL	157.58 mL	315.16 mL
0.5 mM	6.3 mL	31.52 mL	63.03 mL
1 mM	3.15 mL	15.76 mL	31.52 mL
5 mM	0.63 mL	3.15 mL	6.3 mL

*The above data is based on the productmolecular weight 317.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14124
作用机制	Inducer (诱导剂)
M. Wt	317.3
Formula	C17H19NO5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	20069-09-4
Synonyms	Piplartine
SMILES	COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O