|Mechanism of action||Inhibitor|
|储存方式||at -20°C 2 years|
|PKI-587 is a highly potent PI3K/mTOR kinase inhibitor that inhibits PI3K-α,β,γ, δ isoforms and mTOR with IC50 of 0.4, 6.0, 5.4, 6.0 and 1.6 nM respectively.|
|Solubility (25°C)*||In vitro||DMSO||2 mg/mL (3.24 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||16.24 mL||81.21 mL||162.42mL|
|0.5 mM||3.25 mL||16.24 mL||32.48 mL|
|1 mM||1.62 mL||8.12 mL||16.24 mL|
|5 mM||0.32 mL||1.62 mL||3.25 mL|
*The above data is based on the productmolecular weight 615.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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