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PKR Inhibitor是一种羟吲哚/咪唑衍生物，可与PKR的ATP结合位点结合并阻断自磷酸化，IC50值为186-210nM。3PKR抑制剂可保护人类神经母细胞瘤细胞免受衣霉素介导的内质网应激触发的细胞损伤。
| In vitro | DMSO | 13 mg/mL (48.45 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.27 mL | 186.36 mL | 372.72 mL |
| 0.5 mM | 7.45 mL | 37.27 mL | 74.54 mL |
| 1 mM | 3.73 mL | 18.64 mL | 37.27 mL |
| 5 mM | 0.75 mL | 3.73 mL | 7.45 mL |
*The above data is based on the productmolecular weight 268.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13538 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 268.3 |
| Formula | C13H8N4OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 608512-97-6 |
| Synonyms | C16, GW 506033X |
| SMILES | C1=CC2=C(C\3=C1NC(=O)/C3=C\C4=CN=CN4)SC=N2 |
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