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Pladienolide B是从链霉菌分离的大环内酯家族的主要类似物。Pladienolide B是缺氧信号和癌细胞增殖的高效抑制剂。Pladienolide B与SF3b复合物结合，阻断了剪接体。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.63 mL | 93.16 mL | 186.32 mL |
| 0.5 mM | 3.73 mL | 18.63 mL | 37.26 mL |
| 1 mM | 1.86 mL | 9.32 mL | 18.63 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.73 mL |
*The above data is based on the productmolecular weight 536.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12699 |
|---|---|
| M. Wt | 536.7 |
| Formula | C30H48O8 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 445493-23-2 |
| SMILES | O[C@H]1CC(O[C@H](/C(C)=C/C=C/[C@@H](C)C[C@@H]2[C@]([C@H](C)[C@H](CC)O)([H])O2)[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC1)=O |
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