Plitidepsin

Name: Plitidepsin
SKU: A22480
Price: 1715 CNY
Rating: 5 (288 reviews)

目录号: A22480

Plitidepsin 是一种从海洋被囊动物 Aplidium albicans 中分离出的环状脱氨肽。Plitidepsin 表现出广泛的抗肿瘤活性，通过触发线粒体细胞色素 c 释放、启动 Fas/DC95、JNK 通路和激活 caspase 3 来诱导凋亡。该药物还抑制了延伸因子 1-a，从而干扰蛋白质合成，并诱导 G1 阻滞和 G2 阻塞，从而抑制肿瘤细胞生长。

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Grouped product items
规格	价格	库存
1mg	¥1,715.00	现货
5mg	¥5,040.00	现货
10mg	¥6,860.00	现货
25mg	¥10,675.00	现货
50mg	¥13,825.00	现货
100mg	¥23,765.00	现货
*10mM 1mL in DMSO**	¥9,275.00	现货
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Data Sheet

SDS

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生物活性

Discription

Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A22480
分子式	C57H87N7O15
分子量	1110.34
CAS号	137219-37-5
SMILES	CC[C@@H]([C@@H]1[C@@H](O)CC(O[C@@H](C(C)C)C([C@H](C)C(N[C@@H](CC(C)C)C(N2CCC[C@H]2C(N(C)[C@@H](CC3=CC=C(OC)C=C3)C(O[C@H](C)[C@H](NC([C@H](N(C([C@@H]4CCCN4C(C(C)=O)=O)=O)C)CC(C)C)=O)C(N1)=O)=O)=O)=O)=O)=O)=O)C
其他名称	aplidine, dehydrodemnin B
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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