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Raf 抑制剂

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产品目录号: A10002


产品名 目录号 价格 数量
PLX-4720 10mg A10002-10
¥ 700.00
PLX-4720 25mg A10002-25
¥ 1,000.00
PLX-4720 50mg A10002-50
¥ 1,500.00
PLX-4720 100mg A10002-100
¥ 2,400.00
PLX-4720 10mM * 1mL in DMSO A10002-10mM-D
¥ 1,000.00



PLX-4720 is a B-raf inhibitor with IC50 of 160 nM.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10002
Mechanism of action Inhibitor
分子量 413.8
化学分子式 C17H14ClF2N3O3S
Solubility DMSO>83mg/mL Water <1mg/mL Ethanol <1mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 918505-84-7
Synonyms PLX4720
SMILES code CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
化学名称 N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide


PLX-4720 is a B-raf inhibitor with IC50 of 160 nM.
Target Value
C-Raf-1(Y340D/Y341D)IC50: 6.7nM
B-Raf(V600E)IC50: 13nM
BRKIC50: 130nM
B-RafIC50: 160nM
FRKIC50: 1.3μM
CSKIC50: 1.5μM
SrcIC50: 1.7μM
FAKIC50: 1.7μM
FGFRIC50: 1.9μM
KDRIC50: 2.3μM
HGKIC50: 2.8μM
CSF-1RIC50: 3.3μM
AuroraAIC50: 3.4μM


Solubility (25°C) * In vitro DMSO 83 mg/mL (200.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% CMC/0.5% Tween-80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.17 mL 120.83 mL 241.66mL
0.5 mM 4.83 mL 24.17 mL 48.33 mL
1 mM 2.42 mL 12.08 mL 24.17 mL
5 mM 0.48 mL 2.42 mL 4.83 mL

*The above data is based on the productmolecular weight 413.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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