PLX-4720

目录号: A10002

Raf inhibitor

PLX-4720 Chemical Structure

CAS NO. 918505-84-7

PLX-4720是一种B-raf抑制剂,IC50为160 nM。

库存: 现货

规格 价格 数量
10 mg
¥ 700.00
25 mg
¥ 1,000.00
50 mg
¥ 1,500.00
100 mg
¥ 2,400.00
10mM * 1mL in DMSO
¥ 1,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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PLX-4720是一种B-raf抑制剂,IC50为160 nM。
Targets
Target Value
C-Raf-1(Y340D/Y341D)IC50: 6.7nM
B-Raf(V600E)IC50: 13nM
BRKIC50: 130nM
B-RafIC50: 160nM
FRKIC50: 1.3μM
CSKIC50: 1.5μM
SrcIC50: 1.7μM
FAKIC50: 1.7μM
FGFRIC50: 1.9μM
KDRIC50: 2.3μM
HGKIC50: 2.8μM
CSF-1RIC50: 3.3μM
AuroraAIC50: 3.4μM
In vitro (25°C) DMSO 83 mg/mL (200.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% CMC/0.5% Tween-80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.17 mL 120.83 mL 241.66 mL
0.5 mM 4.83 mL 24.17 mL 48.33 mL
1 mM 2.42 mL 12.08 mL 24.17 mL
5 mM 0.48 mL 2.42 mL 4.83 mL

*The above data is based on the productmolecular weight 413.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10002
MECHANISM OF ACTION Inhibitor
M. Wt 413.8
Formula C17H14ClF2N3O3S
Solubility DMSO>83mg/mL Water <1mg/mL Ethanol <1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 918505-84-7
Synonyms PLX4720
SMILES CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F

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