PLX4032 (Vemurafenib)

目录号: A10739

Raf 抑制剂

PLX4032 (Vemurafenib)

PLX4032 (Vemurafenib) Chemical Structure

CAS NO. 918504-65-1

PLX4032(Vemurafenib)也称为RG7204,Vemurafenib,R7204;RO5185426。 PLX4032是B-raf抑制剂,IC50为44 nM。

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
50 mg
¥ 900.00
100 mg
¥ 1,200.00
200 mg
¥ 2,000.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PLX4032(Vemurafenib)也称为RG7204,Vemurafenib,R7204;RO5185426。 PLX4032是B-raf抑制剂,IC50为44 nM。
Targets
Target Value
SRMSIC50: 18nM
ACK1IC50: 19nM
B-Raf(V600E)IC50: 31nM
C-RafIC50: 48nM
MAP4K5(KHS1)IC50: 51nM
FGRIC50: 63nM
B-RafIC50: 100nM
LCKIC50: 183nM
BRKIC50: 213nM
NEK11IC50: 317nM
BLKIC50: 547nM
LynBIC50: 599nM
YES1IC50: 604nM
WNK3IC50: 877nM
MNK2IC50: 1.717μM
FRK(PTK5)IC50: 1.884μM
CSKIC50: 2.339μM
SrcIC50: 2.389μM
In vitro (25°C) DMSO 98 mg/mL (200.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.41 mL 102.06 mL 204.12 mL
0.5 mM 4.08 mL 20.41 mL 40.82 mL
1 mM 2.04 mL 10.21 mL 20.41 mL
5 mM 0.41 mL 2.04 mL 4.08 mL

*The above data is based on the productmolecular weight 489.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10739
作用机制 Inhibitor (抑制剂)
M. Wt 489.9
Formula C23H18ClF2N3O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 918504-65-1
Synonyms RG7204,RO5185426,Zelboraf, PLX-4032
SMILES CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F

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