Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

PLX4032 (Vemurafenib)

促销

Raf 抑制剂

0 Customer Reviews
产品目录号: A10739

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PLX4032 10mg A10739-10
¥ 400.00
PLX4032 50mg A10739-50
¥ 900.00
PLX4032 100mg A10739-100
¥ 1,200.00
PLX4032 200mg A10739-200
¥ 2,000.00
PLX4032 10mM * 1mL in DMSO A10739-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.

PLX4032 (Vemurafenib)

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PLX4032 (Vemurafenib) 发表的文献 (7)
  • Kudo K, .et al. Cell surface CD63 increased by up-regulated polylactosamine modification sensitizes human melanoma cells to the BRAF inhibitor PLX4032, FASEB J, 2018, Dec 3:fj201800664RR PMID: 30508500
  • Min Ho Choe, .et al. miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP, Cell Death Dis, 2018, Jun; 9(6): 640 PMID: 29844307
  • Jan D?rrie, .et al. BRAF and MEK Inhibitors Influence the Function of Reprogrammed T Cells: Consequences for Adoptive T-Cell Therapy, Int J Mol Sci, 2018, Jan; 19(1): 289 PMID: 29346301
  • Aishwarya Kundu, .et al. Inhibition of Oncogenic BRAF Activity by Indole-3-Carbinol Disrupts Microphthalmia-Associated Transcription Factor Expression and Arrests Melanoma Cell Proliferation, Mol Carcinog, 2017, Jan; 56(1): 49每61. PMID: 26878440
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Toshinori Sueda, .et al. BRAFV600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells, Sci Rep, 2016, 6: 18949 PMID: 26750638
  • Yanling Li, .et al. Tyrphostin AG1296, a platelet-derived growth factor receptor inhibitor, induces apoptosis, and reduces viability and migration of PLX4032-resistant melanoma cells, Onco Targets Ther., 2015, 8: 1043每1051 PMID: 25999739

Chemical Information

目录号 A10739
Mechanism of action Inhibitor
分子量 489.9
化学分子式 C23H18ClF2N3O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 918504-65-1
Synonyms RG7204,RO5185426,Zelboraf, PLX-4032
SMILES code CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F
化学名称 N-[2,4-Difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-2-propanesulfonamide

生物活性

Description
PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.
Targets
Target Value
SRMSIC50: 18nM
ACK1IC50: 19nM
B-Raf(V600E)IC50: 31nM
C-RafIC50: 48nM
MAP4K5(KHS1)IC50: 51nM
FGRIC50: 63nM
B-RafIC50: 100nM
LCKIC50: 183nM
BRKIC50: 213nM
NEK11IC50: 317nM
BLKIC50: 547nM
LynBIC50: 599nM
YES1IC50: 604nM
WNK3IC50: 877nM
MNK2IC50: 1.717μM
FRK(PTK5)IC50: 1.884μM
CSKIC50: 2.339μM
SrcIC50: 2.389μM

溶解性

Solubility (25°C) * In vitro DMSO 98 mg/mL (200.03 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.41 mL 102.06 mL 204.12mL
0.5 mM 4.08 mL 20.41 mL 40.82 mL
1 mM 2.04 mL 10.21 mL 20.41 mL
5 mM 0.41 mL 2.04 mL 4.08 mL

*The above data is based on the productmolecular weight 489.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 PLX4032 (Vemurafenib) | PLX4032 (Vemurafenib) 供应商 | 订购 PLX4032 (Vemurafenib) | PLX4032 (Vemurafenib) 价格 | PLX4032 (Vemurafenib) 生产商 | 订单 PLX4032 (Vemurafenib) | PLX4032 (Vemurafenib) 代理商 | 购买 918504-65-1| 918504-65-1 供应商 | 订购 918504-65-1 | 918504-65-1 价格 | 918504-65-1 生产商 | 订单 918504-65-1 | 918504-65-1 代理商|buy PLX4032 (Vemurafenib) | PLX4032 (Vemurafenib) Supplier | purchase PLX4032 (Vemurafenib) | PLX4032 (Vemurafenib) cost | PLX4032 (Vemurafenib) manufacturer | order PLX4032 (Vemurafenib) | PLX4032 (Vemurafenib) distributor | buy 918504-65-1| 918504-65-1 Supplier | purchase 918504-65-1 | 918504-65-1 cost | 918504-65-1 manufacturer | order 918504-65-1 | 918504-65-1 distributor