PLX51107

Name: PLX51107
SKU: A18345

目录号: A18345

selective BET inhibitor

PLX51107 Chemical Structure

CAS NO. 1627929-55-8

PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively; PLX51107 also interacts with the bromodomains of CBP and EP300 (Kd, in the 100 nM range).

库存：现货

规格	价格	数量
5 mg	￥ 1,800.00
10 mg	￥ 3,200.00
50 mg	￥ 10,000.00
100 mg	￥ 17,000.00

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产品详情

生物活性

溶解度 *

In vitro	DMSO	84 mg/mL (191.57 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.81 mL	114.03 mL	228.06 mL
0.5 mM	4.56 mL	22.81 mL	45.61 mL
1 mM	2.28 mL	11.4 mL	22.81 mL
5 mM	0.46 mL	2.28 mL	4.56 mL

*The above data is based on the productmolecular weight 438.487. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18345
作用机制	Inhibitor (抑制剂)
M. Wt	438.487
Formula	C26H22N4O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1627929-55-8
Synonyms	PLX-51107, PLX 51107
SMILES	C[C@@H](C1=NC=CC=C1)N2C=C(C3=CC=C(C(O)=O)C=C3)C4=NC=C(C5=C(C)ON=C5C)C=C42