PLX7904

Name: PLX7904
SKU: A15855
Price: 280 CNY
Rating: 5 (288 reviews)

目录号: A15855

Raf 抑制剂

PLX7904 是一种强效且选择性的悖论破解型RAF抑制剂。它能有效抑制突变型BRAF黑色素瘤细胞中ERK1/2的激活，但不会在表达突变型RAS的细胞中过度激活ERK1/2。

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Grouped product items
规格	价格	库存
5mg	¥280.00	现货
10mg	¥525.00	现货
25mg	¥1,225.00	现货
50mg	¥1,785.00	现货
100mg	¥3,255.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription

PLX7904 is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.

Targets

Target	Value

产品信息

目录号	A15855
分子式	C24H22F2N6O3S
分子量	512.53
CAS号	1393465-84-3
SMILES	O=C(C1=CNC2=NC=C(C3=CN=C(C4CC4)N=C3)C=C21)C5=C(F)C=CC(NS(=O)(N(CC)C)=O)=C5F
其他名称	PB04
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	87 mg/mL (169.75 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.51 mL	97.56 mL	195.11 mL
0.5 mM	3.9 mL	19.51 mL	39.02 mL
1 mM	1.95 mL	9.76 mL	19.51 mL
5 mM	0.39 mL	1.95 mL	3.9 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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