Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antibody that functions as an antagonist by selectively targeting and binding to LILRB2. This interaction inhibits LILRB2 from associating with its natural ligands, including both classical and non-classical MHC class I molecules. By preventing LILRB2 from binding to HLA-A/B and HLA-G, which are markers of immunotolerance on tumor cells, Polzastobart effectively disrupts this inhibitory signal and enhances the production of pro-inflammatory cytokines in macrophages. This mechanism classifies Polzastobart as a macrophage immune checkpoint inhibitor, making it a critical tool in cancer immunotherapy research.
Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antibody that functions as an antagonist by selectively targeting and binding to LILRB2. This interaction inhibits LILRB2 from associating with its natural ligands, including both classical and non-classical MHC class I molecules. By preventing LILRB2 from binding to HLA-A/B and HLA-G, which are markers of immunotolerance on tumor cells, Polzastobart effectively disrupts this inhibitory signal and enhances the production of pro-inflammatory cytokines in macrophages. This mechanism classifies Polzastobart as a macrophage immune checkpoint inhibitor, making it a critical tool in cancer immunotherapy research.
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