Ponsegromab (PF 06946860) is a potent, selective humanized monoclonal antibody targeting GDF15, designed to inhibit its interaction with the GFRAL receptor. By binding to GDF15, Ponsegromab effectively prevents GDF15 from engaging with the GFRAL receptor, thereby obstructing the GDF15/GFRAL-mediated signaling pathway. This antibody exhibits significant anti-cachexia activity, making it a valuable tool for research in oncology settings where cachexia is prevalent.
Ponsegromab (PF 06946860) is a potent, selective humanized monoclonal antibody targeting GDF15, designed to inhibit its interaction with the GFRAL receptor. By binding to GDF15, Ponsegromab effectively prevents GDF15 from engaging with the GFRAL receptor, thereby obstructing the GDF15/GFRAL-mediated signaling pathway. This antibody exhibits significant anti-cachexia activity, making it a valuable tool for research in oncology settings where cachexia is prevalent.
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