Posaconazole
目录号: A10744
CYP3A4 抑制剂
泊沙康唑主要是CYP3A4的抑制剂,但它不抑制其他CYP酶的活性;同时也是sterol C14α-demethylase的抑制剂,其IC50为0.25微摩尔。泊沙康唑的中位末端消除半衰期为15-35小时。
Discription | Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14?? demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours. | |||||
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Targets |
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Cell Research |
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目录号 | A10744 |
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分子式 | C37H42F2N8O4 |
分子量 | 700.8 |
CAS号 | 171228-49-2 |
SMILES | CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F |
其他名称 | Noxafil |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 90 mg/mL (128.42 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 14.27 mL | 71.35 mL | 142.69 mL |
0.5 mM | 2.85 mL | 14.27 mL | 28.54 mL |
1 mM | 1.43 mL | 7.13 mL | 14.27 mL |
5 mM | 0.29 mL | 1.43 mL | 2.85 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2