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Posaconazole

促销

CYP3A4 抑制剂

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产品目录号: A10744

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Posaconazole 5mg A10744-5
¥ 600.00
Posaconazole 10mg A10744-10
¥ 1,000.00
Posaconazole 25mg A10744-25
¥ 1,800.00
Posaconazole 50mg A10744-50
¥ 3,000.00
Posaconazole 10mM * 1mL in DMSO A10744-10mM-D
¥ 1,430.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.

Posaconazole

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Chemical Information

目录号 A10744
Mechanism of action Inhibitor
分子量 700.8
化学分子式 C37H42F2N8O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 171228-49-2
Synonyms Noxafil
SMILES code CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F
化学名称 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

生物活性

Description
Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM. Posaconazole has a median terminal elimination half-life of 15-35 hours.
Targets
lanosterol 14α-demethylase

溶解性

Solubility (25°C) * In vitro DMSO 140 mg/mL (199.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.27 mL 71.35 mL 142.69mL
0.5 mM 2.85 mL 14.27 mL 28.54 mL
1 mM 1.43 mL 7.13 mL 14.27 mL
5 mM 0.29 mL 1.43 mL 2.85 mL

*The above data is based on the productmolecular weight 700.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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