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Poziotinib

促销

EGFR 抑制剂

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产品目录号: A13044

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Poziotinib 5mg A13044-5
¥ 700.00
Poziotinib 10mg A13044-10
¥ 1,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Poziotinib is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.

Poziotinib

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Chemical Information

目录号 A13044
Mechanism of action Inhibitor
分子量 491.34
化学分子式 C23H21Cl2FN4O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1092364-38-9
Synonyms HM781-36B, NOV120101, NOV-120101, NOV 120101
SMILES code COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C
化学名称 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one

生物活性

Description
Poziotinib is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
Targets
HER1 HER2 HER4
3.2 nM5.3 nM23.5 nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.35 mL 101.76 mL 203.53mL
0.5 mM 4.07 mL 20.35 mL 40.71 mL
1 mM 2.04 mL 10.18 mL 20.35 mL
5 mM 0.41 mL 2.04 mL 4.07 mL

*The above data is based on the productmolecular weight 491.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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