PP1

目录号: A12724

Src Inhibitor

PP1 Chemical Structure

CAS NO. 172889-26-8

PP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl

库存: 现货

规格 价格 数量
10 mg
¥ 1,000.00
25 mg
¥ 2,200.00
50 mg
¥ 3,200.00
100 mg
¥ 5,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl
Targets
Target Value
LCKIC50: 5nM
FynIC50: 6nM
KitIC50: ~75nM
EGFRIC50: 250nM
Bcr-AblIC50: 1μM
JAK2IC50: >50μM
ZAP70IC50: >100μM
In vitro DMSO 4 mg/mL (14.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.54 mL 177.71 mL 355.42 mL
0.5 mM 7.11 mL 35.54 mL 71.08 mL
1 mM 3.55 mL 17.77 mL 35.54 mL
5 mM 0.71 mL 3.55 mL 7.11 mL

*The above data is based on the productmolecular weight 281.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12724
MECHANISM OF ACTION Inhibitor
M. Wt 281.36
Formula C16H19N5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 172889-26-8
Synonyms PP-1, PP 1
SMILES CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C

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