PP121

目录号: A11207

PI3K 抑制剂

PP121

PP121 Chemical Structure

CAS NO. 1092788-83-4

PP121是一种作用于PDGFR,Hck,mTOR,VEGFR2,Src和Abl的多靶点抑制剂,IC50分别为2 nM,8 nM,10 nM,12 nM,14 nM和18 nM,也抑制DNA-PK,IC50为60 nM。

库存: 现货

规格 价格 数量
10 mg
¥ 800.00
25 mg
¥ 1,600.00
50 mg
¥ 2,800.00
100 mg
¥ 4,500.00
10mM * 1mL in DMSO
¥ 850.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PP121是一种作用于PDGFR,Hck,mTOR,VEGFR2,Src和Abl的多靶点抑制剂,IC50分别为2 nM,8 nM,10 nM,12 nM,14 nM和18 nM,也抑制DNA-PK,IC50为60 nM。
Targets
Target Value
PDGFRIC50: 2nM
HckIC50: 8nM
VEGFRIC50: 12nM
mTORIC50: 13nM
SrcIC50: 14nM
AblIC50: 18nM
p110αIC50: 52nM
DNA-PKIC50: 60nM
p110δIC50: 150nM
EphB4IC50: 190nM
EGFRIC50: 260nM
p110γIC50: 1.1μM
p110βIC50: 1.4μM
In vitro DMSO 63 mg/mL (197.27 mM)
Water Insoluble
Ethanol 2 mg/mL (6.26 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.31 mL 156.56 mL 313.13 mL
0.5 mM 6.26 mL 31.31 mL 62.63 mL
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL

*The above data is based on the productmolecular weight 319.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11207
作用机制 Inhibitor (抑制剂)
M. Wt 319.36
Formula C17H17N7
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1092788-83-4
Synonyms PP-121
SMILES C1CCC(C1)N2C3=C(C(=N2)C4=CN=C5C(=C4)C=CN5)C(=NC=N3)N

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