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PP121

促销

PI3K 抑制剂

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产品目录号: A11207

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PP121 10mg A11207-10
¥ 800.00
PP121 25mg A11207-25
¥ 1,600.00
PP121 50mg A11207-50
¥ 2,800.00
PP121 100mg A11207-100
¥ 4,500.00
PP121 10mM * 1mL in DMSO A11207-10mM-D
¥ 850.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).

PP121

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Chemical Information

目录号 A11207
Mechanism of action Inhibitor
分子量 319.36
化学分子式 C17H17N7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1092788-83-4
Synonyms PP-121
SMILES code C1CCC(C1)N2C3=C(C(=N2)C4=CN=C5C(=C4)C=CN5)C(=NC=N3)N
化学名称 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]p yridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

生物活性

Description
PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).
Targets
Target Value
PDGFRIC50: 2nM
HckIC50: 8nM
VEGFRIC50: 12nM
mTORIC50: 13nM
SrcIC50: 14nM
AblIC50: 18nM
p110αIC50: 52nM
DNA-PKIC50: 60nM
p110δIC50: 150nM
EphB4IC50: 190nM
EGFRIC50: 260nM
p110γIC50: 1.1μM
p110βIC50: 1.4μM

溶解性

Solubility (25°C)* In vitro DMSO 64 mg/mL (200.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.26 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.31 mL 156.56 mL 313.13mL
0.5 mM 6.26 mL 31.31 mL 62.63 mL
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL

*The above data is based on the productmolecular weight 319.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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