PP2

目录号: A12723

Src Inhibitor

PP2

PP2 Chemical Structure

CAS NO. 172889-27-9

PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).

库存: 现货

规格 价格 数量
10 mg
¥ 1,000.00
25 mg
¥ 2,200.00
50 mg
¥ 3,000.00
100 mg
¥ 5,000.00
10mM * 1mL in DMSO
¥ 900.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).
Targets
LCK (Cell-free assay) Fyn (Cell-free assay) EGFR (Cell-free assay) JAK2 (Cell-free assay) ZAP70 (Cell-free assay)
4 nM5 nM480 nM>50 μM>100 μM
In vitro (25°C) DMSO 60 mg/mL (198.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.62 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.18 mL 160.89 mL 321.77 mL
0.5 mM 6.44 mL 32.18 mL 64.35 mL
1 mM 3.22 mL 16.09 mL 32.18 mL
5 mM 0.64 mL 3.22 mL 6.44 mL

*The above data is based on the productmolecular weight 310.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A12723
MECHANISM OF ACTION Inhibitor
M. Wt 310.78
Formula C15H16ClN5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 172889-27-9
Synonyms PP-2, PP 2
SMILES CC(C)(C)N1C2=C(C(=N1)C3=CC=C(C=C3)Cl)C(=NC=N2)N

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