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PP2

促销

Src 抑制剂

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产品目录号: A12723

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PP2 10mg A12723-10
¥ 1,000.00
PP2 25mg A12723-25
¥ 2,200.00
PP2 50mg A12723-50
¥ 3,000.00
PP2 100mg A12723-100
¥ 5,000.00
PP2 10mM * 1mL in DMSO A12723-10mM-D
¥ 900.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).

PP2

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Chemical Information

目录号 A12723
Mechanism of action Inhibitor
分子量 310.78
化学分子式 C15H16ClN5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 172889-27-9
Synonyms PP-2, PP 2
SMILES code CC(C)(C)N1C2=C(C(=N1)C3=CC=C(C=C3)Cl)C(=NC=N2)N
化学名称 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3?,4-d]pyrimidin-4-amine

生物活性

Description
PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).
Targets
LCK (Cell-free assay) Fyn (Cell-free assay) EGFR (Cell-free assay) JAK2 (Cell-free assay) ZAP70 (Cell-free assay)
4 nM5 nM480 nM>50 μM>100 μM

溶解性

Solubility (25°C) * In vitro DMSO 60 mg/mL (198.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.62 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.18 mL 160.89 mL 321.77mL
0.5 mM 6.44 mL 32.18 mL 64.35 mL
1 mM 3.22 mL 16.09 mL 32.18 mL
5 mM 0.64 mL 3.22 mL 6.44 mL

*The above data is based on the productmolecular weight 310.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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