Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

PP242 (Torkinib)

促销

mTOR 抑制剂

0 Customer Reviews
产品目录号: A10746

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PP242 5mg A10746-5
¥ 500.00
PP242 10mg A10746-10
¥ 700.00
PP242 50mg A10746-50
¥ 1,700.00
PP242 100mg A10746-100
¥ 3,100.00
PP242 10mM * 1mL in DMSO A10746-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.

PP242 (Torkinib)

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PP242 (Torkinib) 发表的文献 (2)
  • Hiroshi Fukamachi, .et al. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors, J Exp Clin Cancer Res, 2019, 38:127
  • Fuse MJ, .et al. Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers, Mol Cancer Ther, 2017, Oct;16(10):2130-2143 PMID: 28751539

Chemical Information

目录号 A10746
Mechanism of action Inhibitor
分子量 308.3
化学分子式 C16H16N6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1092351-67-1
Synonyms PP-242
SMILES code CC(C)N1C2=C(/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)C(=NC=N2)N
化学名称 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol

生物活性

Description
PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.
Targets
Target Value
mTORIC50: 8nM
p110δIC50: 0.10μM
DNA-PKIC50: 0.41μM
PDGFRIC50: 0.41μM
HckIC50: 1.2μM
p110γIC50: 1.3μM
SrcIC50: 1.4μM
VEGFR2IC50: 1.5μM
p110αIC50: 2.0μM
p110βIC50: 2.2μM
EphB4IC50: 3.4μM
AblIC50: 3.6μM
EGFRIC50: 4.4μM
Src(T338I)IC50: 5.1μM

溶解性

Solubility (25°C) * In vitro DMSO 62 mg/mL (201.07 mM)
Water <1 mg/mL (<1 mM)
Ethanol 18 mg/mL (58.37 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.44 mL 162.18 mL 324.36mL
0.5 mM 6.49 mL 32.44 mL 64.87 mL
1 mM 3.24 mL 16.22 mL 32.44 mL
5 mM 0.65 mL 3.24 mL 6.49 mL

*The above data is based on the productmolecular weight 308.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。


Keywords:购买 PP242 (Torkinib) | PP242 (Torkinib) 供应商 | 订购 PP242 (Torkinib) | PP242 (Torkinib) 价格 | PP242 (Torkinib) 生产商 | 订单 PP242 (Torkinib) | PP242 (Torkinib) 代理商 | 购买 1092351-67-1| 1092351-67-1 供应商 | 订购 1092351-67-1 | 1092351-67-1 价格 | 1092351-67-1 生产商 | 订单 1092351-67-1 | 1092351-67-1 代理商|buy PP242 (Torkinib) | PP242 (Torkinib) Supplier | purchase PP242 (Torkinib) | PP242 (Torkinib) cost | PP242 (Torkinib) manufacturer | order PP242 (Torkinib) | PP242 (Torkinib) distributor | buy 1092351-67-1| 1092351-67-1 Supplier | purchase 1092351-67-1 | 1092351-67-1 cost | 1092351-67-1 manufacturer | order 1092351-67-1 | 1092351-67-1 distributor