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PP242 (Torkinib)


mTOR 抑制剂

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产品目录号: A10746


产品名 目录号 价格 数量
PP242 5mg A10746-5
¥ 500.00
PP242 10mg A10746-10
¥ 700.00
PP242 50mg A10746-50
¥ 1,700.00
PP242 100mg A10746-100
¥ 3,100.00
PP242 10mM * 1mL in DMSO A10746-10mM-D
¥ 500.00



PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.

PP242 (Torkinib)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PP242 (Torkinib) 发表的文献 (2)
  • Hiroshi Fukamachi, .et al. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors, J Exp Clin Cancer Res, 2019, 38:127
  • Fuse MJ, .et al. Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers, Mol Cancer Ther, 2017, Oct;16(10):2130-2143 PMID: 28751539

Chemical Information

目录号 A10746
Mechanism of action Inhibitor
分子量 308.3
化学分子式 C16H16N6O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1092351-67-1
Synonyms PP-242
SMILES code CC(C)N1C2=C(/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)C(=NC=N2)N
化学名称 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol


PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.
Target Value
mTORIC50: 8nM
p110δIC50: 0.10μM
DNA-PKIC50: 0.41μM
PDGFRIC50: 0.41μM
HckIC50: 1.2μM
p110γIC50: 1.3μM
SrcIC50: 1.4μM
VEGFR2IC50: 1.5μM
p110αIC50: 2.0μM
p110βIC50: 2.2μM
EphB4IC50: 3.4μM
AblIC50: 3.6μM
EGFRIC50: 4.4μM
Src(T338I)IC50: 5.1μM


Solubility (25°C) * In vitro DMSO 62 mg/mL (201.07 mM)
Water <1 mg/mL (<1 mM)
Ethanol 18 mg/mL (58.37 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.44 mL 162.18 mL 324.36mL
0.5 mM 6.49 mL 32.44 mL 64.87 mL
1 mM 3.24 mL 16.22 mL 32.44 mL
5 mM 0.65 mL 3.24 mL 6.49 mL

*The above data is based on the productmolecular weight 308.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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