PROTAC ER Degrader-3

目录号: A18519

PROTAC ER Degrader-3

PROTAC ER Degrader-3 Chemical Structure

CAS NO. 2158322-29-1

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

库存: 现货

规格 价格 数量
5 mg
¥ 4,680.00
10 mg
¥ 8,060.00
50 mg
¥ 23,920.00
100 mg
¥ 47,840.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.19 mL 40.97 mL 81.94 mL
0.5 mM 1.64 mL 8.19 mL 16.39 mL
1 mM 0.82 mL 4.1 mL 8.19 mL
5 mM 0.16 mL 0.82 mL 1.64 mL

*The above data is based on the productmolecular weight 1220.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A18519
作用机制 Degrader (降解剂)
M. Wt 1220.41
Formula C71H77N7O12
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 2158322-29-1
SMILES OC1=CC=C(/C(C2=CC=C(OCCN(C)C(COCCOCCNC(C3=CC=C(C(N4[C@@H](C)[C@H](NC([C@H](C)N(C(OC(C)(C)C)=O)C)=O)C(N(CC5=C(OC)C=CC6=C5C=CC=C6)C7=C4C=C(C#N)C=C7)=O)=O)C=C3)=O)=O)C=C2)=C(CC)/C8=CC=CC=C8)C=C1

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