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PROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.8 mL | 49.01 mL | 98.02 mL |
| 0.5 mM | 1.96 mL | 9.8 mL | 19.6 mL |
| 1 mM | 0.98 mL | 4.9 mL | 9.8 mL |
| 5 mM | 0.2 mL | 0.98 mL | 1.96 mL |
*The above data is based on the productmolecular weight 1020.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18682 |
|---|---|
| 作用机制 | Degrader (降解剂) |
| M. Wt | 1020.23 |
| Formula | C52H61N9O9S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2230826-81-8 |
| SMILES | O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCOCCOCCOC4=CC5=C(N6C(S5)=NC(C7=CC=C(NC(NC8=NOC(C(C)(C)C)=C8)=O)C=C7)=C6)C=C4 |
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