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PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.72 mL | 58.62 mL | 117.24 mL |
| 0.5 mM | 2.34 mL | 11.72 mL | 23.45 mL |
| 1 mM | 1.17 mL | 5.86 mL | 11.72 mL |
| 5 mM | 0.23 mL | 1.17 mL | 2.34 mL |
*The above data is based on the productmolecular weight 852.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20005 |
|---|---|
| 作用机制 | Degrader (降解剂) |
| M. Wt | 852.94 |
| Formula | C40H40N10O8S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2098487-75-1 |
| SMILES | O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN4C=C(COC5=CC(CC6=CN=C(NC(CSC7=NC(C)=CC(C)=N7)=O)S6)=CC=C5)N=N4)=O |
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