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PRT062607 HCL

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Syk 抑制剂

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产品目录号: A12731

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PRT062607 HCL 5mg A12731-5
¥ 900.00
PRT062607 HCL 10mg A12731-10
¥ 1,600.00
PRT062607 HCL 25mg A12731-25
¥ 3,000.00
PRT062607 HCL 50mg A12731-50
¥ 4,800.00
PRT062607 HCL 10mM * 1mL in DMSO A12731-10mM-D
¥ 1,250.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

PRT062607 HCL

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Chemical Information

目录号 A12731
Mechanism of action Inhibitor
分子量 429.91
化学分子式 C19H24ClN9O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1370261-97-4
Synonyms P505-15, PRT2607, PRT-2607, PRT 2607, PRT-062607, PRT 062607, P505-15, BIIB057
SMILES code C1CC[C@H]([C@H](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N.Cl
化学名称 4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide hydrochloride

生物活性

Description
PRT2607, also known as PRT062607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.
Targets
Target Value
SykIC50: 1nM
FGRIC50: 81nM
MLK1IC50: 88nM
YESIC50: 123nM
FLT3IC50: 139nM
PAK5IC50: 166nM
LynIC50: 192nM
c-SrcIC50: 244nM
LCKIC50: 249nM

溶解性

Solubility (25°C) * In vitro DMSO 86 mg/mL (200.04 mM)
Water 86 mg/mL (200.04 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.26 mL 116.3 mL 232.61mL
0.5 mM 4.65 mL 23.26 mL 46.52 mL
1 mM 2.33 mL 11.63 mL 23.26 mL
5 mM 0.47 mL 2.33 mL 4.65 mL

*The above data is based on the productmolecular weight 429.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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